Engineering for Health and Wellbeing Group

People - Scaglione Silvia

Silvia Scaglione is born in Genoa, Italy, in 1977 and received the M. Sc. degree in Biomedical Engineering from the University of Genoa in 2001. In 2005 she has completed her Ph.D. in Bioengineering and Bioelectronics at the University of Genoa. In 2004 she was visiting scientist at the University Hospital of Basel, Switzerland. From 2005 to 2010 she has collaborated with University of Genoa (DIST department) and Advanced Biotechnology Center as post-doc researcher. In 2010 she joined the Institute of Electronics, Computer and Telecommunication Engineering (IEIIT) of the Italian National Research Council (CNR), where she is researcher.

Her research interests include tissue engineering, biomaterial science, and bioinformatics. Her activity is mainly centered on the development of new intelligent scaffods as bone/cartilage substitutes. In one of the possible approaches to this aim, living cells are used to generate ex-vivo implantable structures, which could cover losses of tissues (e.g., as a result of trauma or tumor surgery), or replace non-functional organs (e.g., to overcome the problem of the reduced availability of organs from healthy donors). Anyway, the possible impact of this field is much wider: in the future, the engineered tissues could not only reduce the need for organs to be transplanted, but may also constitute model systems of tissues ex vivo, which would allow speeding up the development of new medicaments and the research for new therapies, in order to improving the tissue regeneration.

Starting from these considerations, the group is actively interested to these topics: a) design, engineering and development of 3D biomaterials as tissue substitutes (i.e. bone, cartilage and osteochondral substitutes); b) design and development of innovative bioreactor systems for stem/progenitor cell culture in 3D environment under proper physical stimulations c) innovative tissue engineering approaches for in vivo tissue regeneration. The engineered constructs are being developed (i) as grafts for the treatment of traumas/diseases of the musculoskeletal system, and/or (ii) as 3D model systems to investigate fundamental aspects of cell differentiation and tissue development under controlled and defined conditions.

Since 2005 she has been supervisor and co-examiner for the Engineer and the Science Faculty of the Genoa University.
She is teacher at the Medical University of Genoa. She is referee for many international journals in the field of tissue engineering and material science. Since 2008 she is MIUR reviser.

Silvia Scaglione is author or co-author of more than 20 scientific publications on international journals, author of many book chapters. She is inventor of 4 patents related to the above described research field.

Silvia Scaglione
CNR-IEIIT Via De Marini, 6
16149 Genova GE, Italia
silvia.scaglione [at]
Tel.+39 010 6475 206